The application of methyl silicon oil in the field of drugs is so wide

1. The best water sparse agent is the best application effect

1. Preparation of anti -acid capsules

22.02kg of glycerin, 34.13kg of distilled water, 10kg of dioma silicon oil, add 43.85kg of gelatin, decompression dissolved with 70-80 ° C, and often make capsules. Formaldehyde/acetone (1/60) mixture is sprayed on the capsule. Due to the hydration effect of dioma silicon oil, the capsules are not disintegrated for 2 hours in acidic gastric juice. They are dissolved 200-620 seconds in alkaline enteric solution. They are stable in enzymes and temperatures and have good mechanical strength.

2. The light of sugar and coat tablets (lighting agent)

When polishing operation, adding 2%of the Sichuan wax pink with 2%dioma silicon oil to the tablet for the packed coat for polishing. The sugar and coat tablets are compared with the non -plus dizen silicon oil. Wide moisture -proof effects to ensure that sugar -coated tablets do not decolorize or mildew during the storage period.

3. Film clothes and coat materials

It is used as a thin film coat material, and the hydrophobic and oxygen resistance of dioma silicon oil is used to isolate the core from the outside. It is not affected by the water, oxygen and other effects in the air.

Second, the best condenser of water -soluble dripping pills

Drops of drops of drops that may occur in the condenser are spreading, forming liquid droplets and mixed. Generally, the surface of the liquid with smaller surface tension will be placed on the surface with a liquid with a large surface tension. Di metal silicon oil is the minimum condenser on the surface of the common water -soluble drop -pill condenser (liquid paraffin 0.035N/m, vegetable oil 0.035 n/m, and 0.021 n/m).

There are many other specifications of the other two silicon oil models. By adjusting the temperature and choosing different types of di metarium silicon oil to adjust the molding and precipitation speed of the liquid droplet in the condenser to achieve the best process and quality status, and no, no There are hidden dangers of polluting petrochemical products that are toxic substances and water -based dripping pills.

In particular, the drip pills that use S-40 (polyoxy vinyl monochrome) and POLOXAMER must be used as a substrate as a matrix. Silicon oil can increase the dissolution of water -soluble active drugs, which is conducive to the absorption of drugs; Poloxamer cannot be used as condensate with liquid paraffin because it is wettable. (Drip Maru produces medium -sized silicon oil regular treatment technology; because the price of di metharma oil is more expensive, it should be used as much as possible during production. The broken pills can be removed by filtering, static settlement or centrifugation; in addition, the common foreign body is water, and when using the mixed oil moisture dizis silicon oil as a condenser, the drip pill may dissolve, deform or even condense and not condense changes. Hard, the method of removing the moisture in the di metharma oil is: freeze the di-based silicon oil with moisture at -4 ° C. After the water is condensed into ice, take it out, and quickly filter it to remove it.

Third, the only effective antistatic agent in the production of microfim and micro pills

The pills or micro pills set up a darrification in the fluidized bed. When the material is sprayed through the spray area, the clothing fog grains are sprayed on its surface. After repeated spraying, the film's film gradually expanded, and finally the continuous overall clothing layer was formed to achieve the purpose of coating. In order to ensure that the safety operation and the material are completely dispersed, the powder is not adhered to the group, and the antistatic agent should be added when the powder spray.

Silicon oil is currently the only medicinal auxiliary material with antistatic effects, which is used as 0.1%of the weight of the powder.

Fourth, the solid preparation is used as a lubricant

The lubricant refers to the addition of liquidity, resistance and lubrication of mobilization, increase the liquidity, anti -stickability and lubrication before pressing the padding material, which is conducive to the general term for the compression process. According to the mechanism of lubricants, it is divided into three types; lubricants refer to auxiliary materials that can reduce the friction between particles or tablets and punching.

After cleaning, applying a layer of silicon oil can also solve the problem of some varieties of adhesion.

1. Slow -release aspirin film

Take 1000g of aspirin powder (0.1770mm in the crystalline diameter), and sigmical anechen ethyl cellulose (including 2%) 70g, soluble at 300ml (1: 1) toluene dioclovenide and 30g of di methallar oil 30g Toluene solution, 400g of starch, 300g of glycerin palmate steamed acid, 50g of talc powder, and 100g of microcrystalline cellulose.

2. Compound heating and dying duty capsules

Take aspirin particles to 50 ° C, use a cluster of 1: 1 methyl acrylic acid and methyl acrocylite and 0.045%AF lotion (foaming agent) coated, dry at 37.8 ° C in the boiling dry bed, and then It is called 52.144g, adding 0.203g of sodium lambssene alcohol, 41.45g of heating polygami, 0.363g of di metarium oil, and polyoxyethylene dehydalized loneline 0.145g mixed evenly. The capsule weighs 700mg, each containing aspirin and heating and polygami 325mg.

3. ibuprofen slow -release film

Take 58.25%of ibuprofen, 14.50%lactose, 12.60%of calcium phosphate, 11.65%of glyceride glycerinate, 1.0%magnesium magnesium.

Fifth, use as a decarling agent in the production process of suppository

The preparation of polish refers to the melting of the drug and the matrix. Pour the suppository mold while it is hot.

Dispatinus oil, liquid paraffin of water -soluble suppository products are commonly used in the massens, and non -petrochemical products such as die meta oil are reduced.

The suppositories that use Poloxamer (Poloxamer) must be used as a dehydent, because Poloxamer is wettable.

6. Safe foaming agent during the recovery process of Chinese medicine and the biological fermentation process

A large amount of air bubbles are often generated during the recovery of Chinese medicine extraction and biological fermentation, resulting in leakage or burst pots. The common method is to add a small amount of foaming agent. Fragmentation can eliminate gas stored by foam during the process of extract and biological fermentation. Commonly custody agents include ether, di methallar oil or other; the components of ether and composite foaming fluid are physiological activity, and their safety is safe. Sex is not recognized.

Silicon oil is the only foaming agent recognized by the drug supervision department.

The dosage of dizis silicon oil is about 10 ml of extract (fermentation liquid) per cubication, which has a significant bubble effect.

7. The main raw materials of medical anti -bubble emulsion

Silicine No. 1 prescription;

Two -meta -with silicon oil (500) 20 ml, 10g of micro -split silicone, and 2 ml of A20, 5%hydroxybenhe hydroxybenterone, and a moderate amount of purified water to make 1000 ml.

For gastroscopy X -ray gastrointestinal examination, it can improve the diagnostic effect; it can also be used to eliminate abdominal distension caused by various reasons.

8. The matrix composition of high -end milk paste products -Silicon oil

It is used as an ointment matrix to improve the penetration ability of the drug to the skin and improve the efficacy; improve the comfort of the patient, and increase the dispersing speed of the drug.

It is a high -end milk cream matrix that is delicate, lubricated and pearl -like, with cosmetics -like sensory intuition and obvious advantages in release speed.

Common formula;

1. Water packaging oil (O/W) type of cream cream matrix;

Active ingredients, oil phase; hexisol, di methane oil, nitrogen ketone, lipidic acid, chip-60; water phase; glycerin, purifying water, etc., the proportion of di methar oil is generally 6-10%. Such as ketonazole milk cream.

2. Oil packing (W/O) type creamy cream matrix;

Active ingredients, oil phase; di methane oil, white Vaselin, single-hard fatty acid glycerin, flat plus A20, water phase; glycerin, purifying water, etc. The proportion of di methane oil is generally 1-5%.

Such as compound ketonazole cream.

3, sunscreen

5 parts of liquid paraffin, 10 parts of white beeswax, 5 copies of micro -spar, 5 copies of di methallar oil, 5 copies of white vaselin, polyoxy ethylene sorgeosol, a single monthly cinnamate, water -loss mountain pearl semioline 5 copies, an appropriate amount of flavors, 1 copy of ampocylmenate, 2 parts of titanium dioxide, and 21 parts of purified water. Because there are ten types of silicon oil different models, but their density and viscosity can be flexibly regulated by the same product. There is always a product or combination of the most suitable specifications to regulate the best preparation product status. This is incomparable with any other similar medicinal auxiliary materials.

It can be seen that di methar oil, as a medicinal auxiliary material and/or drug activity ingredients, is not only good and very safe.

Nine, Dimin Silicon oil in medical devices, pharmaceutical packaging products, application technology

Siliconization; refers to the process of spraying di metharma oil (or diluted diluted solution of di methane oil) on the surface of the appliance or material, and then dried so that the appliance or material surface is applied to a layer of thin -layer thin layer. The degree of siliconization is generally suitable for 0.012-0.02mg/c㎡. After the product is siliconized, the relevant performance has been significantly improved.

1. After the dental materials are treated with siliconization, the compatibility will be significantly improved.

2. After the surgical equipment and injection needle, after the surface of the surface of the injection needle, it can reduce the damage to the tissue and easily puncture;

3. Since the di metharma oil is anticoagulant, the surface of vacuum vascular, blood storage, and hemodialysis equipment can be prolonged by the storage time of blood -sized storage and blood bubbles of the blood circulation device.

4. The friction coefficient on the surface of Tinto rubber plugs is very high. It is necessary to deal with the surface of the plug. Siliconization is a traditional method that overcomes the problem and mechanical problems.

5. After the surface of the disposable dressing, such as gauze, cotton cotton, etc., it can make it non -bonding with the wound;

6. For the lubrication oil for medical appliances, such as the lubrication of a needle for one -time injection, is the safest lubricant;

7. Silicon oil is the best non -benzene lubricant for condoms;

8. Silicon oil can be used directly for shallow burning, scald first aid (homemare) and scarring scars;

9. Silicon oil is a lubricant that can be used for no safety hazards that can be used in the human life of middle -aged and elderly people.

Because industrial di methar oil and di methar oil drugs have huge differences in raw materials, production processes, production environment, quality monitoring, quality standards, and impurities, etc., the product quality differences are obvious. Industrial di methar oil contains a variety of chemicals with complex components and harmful to the human body, and there is no relevant testing method for conventional standards. Therefore, it is recommended that drugs, medical devices, food and cosmetics produces To ensure the safety of this kind of product that is directly related to the health of the masses.